epistasis_id stringlengths 37 51 | arm stringclasses 2
values | gene stringclasses 329
values | chrom int64 1 22 | mut1 stringlengths 18 25 | mut2 stringlengths 18 25 | distance int64 1 100 | n_mut1 int64 3 254 | n_mut2 int64 3 254 | n_both int64 0 251 |
|---|---|---|---|---|---|---|---|---|---|
DOCK10:2:225000175:T:C|DOCK10:2:225000225:G:C | observed | DOCK10 | 2 | DOCK10:2:225000175:T:C | DOCK10:2:225000225:G:C | 50 | 8 | 201 | 1 |
NDUFS8:11:68036297:G:C|NDUFS8:11:68036372:C:G | observed | NDUFS8 | 11 | NDUFS8:11:68036297:G:C | NDUFS8:11:68036372:C:G | 75 | 8 | 3 | 3 |
RBSN:3:15081483:C:G|RBSN:3:15081489:C:G | observed | RBSN | 3 | RBSN:3:15081483:C:G | RBSN:3:15081489:C:G | 6 | 5 | 5 | 5 |
KCNN3:1:154698343:G:C|KCNN3:1:154698344:A:C | observed | KCNN3 | 1 | KCNN3:1:154698343:G:C | KCNN3:1:154698344:A:C | 1 | 19 | 19 | 19 |
RNF40:16:30761991:G:A|RNF40:16:30762064:A:G | observed | RNF40 | 16 | RNF40:16:30761991:G:A | RNF40:16:30762064:A:G | 73 | 73 | 8 | 1 |
CHD8:14:21442680:A:G|CHD8:14:21442718:A:G | observed | CHD8 | 14 | CHD8:14:21442680:A:G | CHD8:14:21442718:A:G | 38 | 77 | 7 | 1 |
SGIP1:1:66735458:C:T|SGIP1:1:66735459:C:T | observed | SGIP1 | 1 | SGIP1:1:66735458:C:T | SGIP1:1:66735459:C:T | 1 | 41 | 86 | 7 |
NOTCH1:9:136536995:T:C|NOTCH1:9:136537053:G:A | observed | NOTCH1 | 9 | NOTCH1:9:136536995:T:C | NOTCH1:9:136537053:G:A | 58 | 163 | 3 | 1 |
BICD2:9:92754964:C:T|BICD2:9:92755045:G:C | observed | BICD2 | 9 | BICD2:9:92754964:C:T | BICD2:9:92755045:G:C | 81 | 42 | 17 | 1 |
GPC6:13:93556859:T:C|GPC6:13:93556896:G:A | observed | GPC6 | 13 | GPC6:13:93556859:T:C | GPC6:13:93556896:G:A | 37 | 7 | 186 | 7 |
CRX:19:47831443:C:T|CRX:19:47831492:C:T | observed | CRX | 19 | CRX:19:47831443:C:T | CRX:19:47831492:C:T | 49 | 162 | 86 | 5 |
COPS5:8:67050541:G:A|COPS5:8:67050612:A:T | observed | COPS5 | 8 | COPS5:8:67050541:G:A | COPS5:8:67050612:A:T | 71 | 228 | 9 | 2 |
LPIN2:18:2995910:G:A|LPIN2:18:2995957:T:C | observed | LPIN2 | 18 | LPIN2:18:2995910:G:A | LPIN2:18:2995957:T:C | 47 | 165 | 54 | 6 |
RBFOX1:16:7024781:C:T|RBFOX1:16:7024842:C:T | observed | RBFOX1 | 16 | RBFOX1:16:7024781:C:T | RBFOX1:16:7024842:C:T | 61 | 23 | 4 | 1 |
AKAP1:17:57120872:A:G|AKAP1:17:57120887:A:T | observed | AKAP1 | 17 | AKAP1:17:57120872:A:G | AKAP1:17:57120887:A:T | 15 | 26 | 230 | 1 |
NFASC:1:204951678:C:T|NFASC:1:204951705:G:A | observed | NFASC | 1 | NFASC:1:204951678:C:T | NFASC:1:204951705:G:A | 27 | 99 | 100 | 99 |
SLC30A4:15:45500622:A:G|SLC30A4:15:45500651:T:C | observed | SLC30A4 | 15 | SLC30A4:15:45500622:A:G | SLC30A4:15:45500651:T:C | 29 | 100 | 4 | 1 |
GOLM2:15:44344211:G:T|GOLM2:15:44344287:G:A | observed | GOLM2 | 15 | GOLM2:15:44344211:G:T | GOLM2:15:44344287:G:A | 76 | 45 | 38 | 2 |
RAB35:12:120110982:C:G|RAB35:12:120110983:T:G | observed | RAB35 | 12 | RAB35:12:120110982:C:G | RAB35:12:120110983:T:G | 1 | 22 | 22 | 22 |
VGLL4:3:11725442:C:T|VGLL4:3:11725451:C:T | observed | VGLL4 | 3 | VGLL4:3:11725442:C:T | VGLL4:3:11725451:C:T | 9 | 30 | 203 | 30 |
PDP1:8:93912352:A:G|PDP1:8:93912362:G:A | observed | PDP1 | 8 | PDP1:8:93912352:A:G | PDP1:8:93912362:G:A | 10 | 32 | 72 | 1 |
ATP10D:4:47537116:G:C|ATP10D:4:47537187:G:A | observed | ATP10D | 4 | ATP10D:4:47537116:G:C | ATP10D:4:47537187:G:A | 71 | 32 | 94 | 4 |
NSD2:4:1907729:C:T|NSD2:4:1907733:C:T | observed | NSD2 | 4 | NSD2:4:1907729:C:T | NSD2:4:1907733:C:T | 4 | 8 | 8 | 8 |
PARVA:11:12453308:C:T|PARVA:11:12453365:T:C | observed | PARVA | 11 | PARVA:11:12453308:C:T | PARVA:11:12453365:T:C | 57 | 25 | 28 | 1 |
PRKCH:14:61373864:A:G|PRKCH:14:61373887:G:A | observed | PRKCH | 14 | PRKCH:14:61373864:A:G | PRKCH:14:61373887:G:A | 23 | 129 | 7 | 2 |
MEF2B:19:19166686:G:A|MEF2B:19:19166707:C:T | observed | MEF2B | 19 | MEF2B:19:19166686:G:A | MEF2B:19:19166707:C:T | 21 | 86 | 100 | 1 |
NDUFS8:11:68036297:G:C|NDUFS8:11:68036345:C:G | observed | NDUFS8 | 11 | NDUFS8:11:68036297:G:C | NDUFS8:11:68036345:C:G | 48 | 8 | 6 | 5 |
RPN1:3:128635630:T:G|RPN1:3:128635696:C:T | observed | RPN1 | 3 | RPN1:3:128635630:T:G | RPN1:3:128635696:C:T | 66 | 223 | 62 | 2 |
SEMA6D:15:47655566:A:G|SEMA6D:15:47655615:A:G | observed | SEMA6D | 15 | SEMA6D:15:47655566:A:G | SEMA6D:15:47655615:A:G | 49 | 118 | 37 | 2 |
ENY2:8:109345079:T:C|ENY2:8:109345095:C:G | observed | ENY2 | 8 | ENY2:8:109345079:T:C | ENY2:8:109345095:C:G | 16 | 6 | 31 | 1 |
NRCAM:7:108254992:T:C|NRCAM:7:108255007:A:G | observed | NRCAM | 7 | NRCAM:7:108254992:T:C | NRCAM:7:108255007:A:G | 15 | 3 | 202 | 1 |
NDUFS8:11:68036297:G:C|NDUFS8:11:68036360:T:C | observed | NDUFS8 | 11 | NDUFS8:11:68036297:G:C | NDUFS8:11:68036360:T:C | 63 | 8 | 3 | 3 |
IGF2BP3:7:23368669:G:A|IGF2BP3:7:23368764:G:A | observed | IGF2BP3 | 7 | IGF2BP3:7:23368669:G:A | IGF2BP3:7:23368764:G:A | 95 | 249 | 21 | 3 |
SMARCA2:9:2175779:T:C|SMARCA2:9:2175837:G:T | observed | SMARCA2 | 9 | SMARCA2:9:2175779:T:C | SMARCA2:9:2175837:G:T | 58 | 17 | 66 | 1 |
KIAA1549L:11:33589404:A:G|KIAA1549L:11:33589480:C:T | observed | KIAA1549L | 11 | KIAA1549L:11:33589404:A:G | KIAA1549L:11:33589480:C:T | 76 | 210 | 7 | 2 |
VXN:8:66493566:A:G|VXN:8:66493587:C:A | observed | VXN | 8 | VXN:8:66493566:A:G | VXN:8:66493587:C:A | 21 | 10 | 8 | 1 |
ACACA:17:37360190:T:C|ACACA:17:37360278:G:A | observed | ACACA | 17 | ACACA:17:37360190:T:C | ACACA:17:37360278:G:A | 88 | 32 | 223 | 9 |
PARD3:10:34149371:T:C|PARD3:10:34149457:T:C | observed | PARD3 | 10 | PARD3:10:34149371:T:C | PARD3:10:34149457:T:C | 86 | 96 | 115 | 6 |
BRWD1:21:39254883:A:G|BRWD1:21:39254957:G:C | observed | BRWD1 | 21 | BRWD1:21:39254883:A:G | BRWD1:21:39254957:G:C | 74 | 92 | 11 | 2 |
FARP1:13:98373984:T:C|FARP1:13:98374055:T:A | observed | FARP1 | 13 | FARP1:13:98373984:T:C | FARP1:13:98374055:T:A | 71 | 123 | 43 | 43 |
FHIP1B:11:6216955:C:T|FHIP1B:11:6217030:T:C | observed | FHIP1B | 11 | FHIP1B:11:6216955:C:T | FHIP1B:11:6217030:T:C | 75 | 4 | 56 | 4 |
BCR:22:23250008:C:T|BCR:22:23250099:C:T | observed | BCR | 22 | BCR:22:23250008:C:T | BCR:22:23250099:C:T | 91 | 20 | 32 | 1 |
PFDN2:1:161109044:T:C|PFDN2:1:161109093:G:T | observed | PFDN2 | 1 | PFDN2:1:161109044:T:C | PFDN2:1:161109093:G:T | 49 | 8 | 16 | 1 |
SEMA6D:15:47655547:C:A|SEMA6D:15:47655615:A:G | observed | SEMA6D | 15 | SEMA6D:15:47655547:C:A | SEMA6D:15:47655615:A:G | 68 | 104 | 37 | 2 |
SRCIN1:17:38601623:C:T|SRCIN1:17:38601662:G:A | observed | SRCIN1 | 17 | SRCIN1:17:38601623:C:T | SRCIN1:17:38601662:G:A | 39 | 50 | 241 | 11 |
USP8:15:50425657:G:T|USP8:15:50425686:T:C | observed | USP8 | 15 | USP8:15:50425657:G:T | USP8:15:50425686:T:C | 29 | 239 | 24 | 1 |
WDR45B:17:82615340:G:C|WDR45B:17:82615429:C:G | observed | WDR45B | 17 | WDR45B:17:82615340:G:C | WDR45B:17:82615429:C:G | 89 | 4 | 103 | 1 |
DMXL1:5:119153479:A:G|DMXL1:5:119153521:C:G | observed | DMXL1 | 5 | DMXL1:5:119153479:A:G | DMXL1:5:119153521:C:G | 42 | 19 | 186 | 2 |
EDNRB:13:77965164:C:T|EDNRB:13:77965180:G:C | observed | EDNRB | 13 | EDNRB:13:77965164:C:T | EDNRB:13:77965180:G:C | 16 | 35 | 3 | 1 |
VGLL4:3:11650713:T:C|VGLL4:3:11650744:C:G | observed | VGLL4 | 3 | VGLL4:3:11650713:T:C | VGLL4:3:11650744:C:G | 31 | 22 | 233 | 2 |
PLAA:9:26939686:T:C|PLAA:9:26939687:G:T | observed | PLAA | 9 | PLAA:9:26939686:T:C | PLAA:9:26939687:G:T | 1 | 6 | 6 | 6 |
RAB23:6:57208283:G:A|RAB23:6:57208375:G:A | observed | RAB23 | 6 | RAB23:6:57208283:G:A | RAB23:6:57208375:G:A | 92 | 4 | 7 | 4 |
HNRNPAB:5:178207787:T:G|HNRNPAB:5:178207872:T:C | observed | HNRNPAB | 5 | HNRNPAB:5:178207787:T:G | HNRNPAB:5:178207872:T:C | 85 | 9 | 195 | 1 |
CD9:12:6211226:A:T|CD9:12:6211232:G:A | observed | CD9 | 12 | CD9:12:6211226:A:T | CD9:12:6211232:G:A | 6 | 94 | 23 | 1 |
FBXO45:3:196577230:T:A|FBXO45:3:196577322:T:C | observed | FBXO45 | 3 | FBXO45:3:196577230:T:A | FBXO45:3:196577322:T:C | 92 | 10 | 93 | 1 |
ATP6V0D1:16:67469476:C:T|ATP6V0D1:16:67469507:G:A | observed | ATP6V0D1 | 16 | ATP6V0D1:16:67469476:C:T | ATP6V0D1:16:67469507:G:A | 31 | 188 | 9 | 1 |
AHNAK:11:62465826:C:T|AHNAK:11:62465876:A:G | observed | AHNAK | 11 | AHNAK:11:62465826:C:T | AHNAK:11:62465876:A:G | 50 | 10 | 8 | 8 |
SPSB1:1:9316927:A:C|SPSB1:1:9316935:G:C | observed | SPSB1 | 1 | SPSB1:1:9316927:A:C | SPSB1:1:9316935:G:C | 8 | 6 | 169 | 1 |
NDUFS8:11:68036297:G:C|NDUFS8:11:68036343:T:C | observed | NDUFS8 | 11 | NDUFS8:11:68036297:G:C | NDUFS8:11:68036343:T:C | 46 | 8 | 7 | 6 |
SUN2:22:38766191:C:A|SUN2:22:38766194:A:C | observed | SUN2 | 22 | SUN2:22:38766191:C:A | SUN2:22:38766194:A:C | 3 | 41 | 19 | 1 |
EIF4G3:1:21150439:A:C|EIF4G3:1:21150521:A:G | observed | EIF4G3 | 1 | EIF4G3:1:21150439:A:C | EIF4G3:1:21150521:A:G | 82 | 9 | 23 | 1 |
RELCH:18:62224714:G:A|RELCH:18:62224725:T:C | observed | RELCH | 18 | RELCH:18:62224714:G:A | RELCH:18:62224725:T:C | 11 | 5 | 134 | 1 |
AKAP1:17:57112860:T:C|AKAP1:17:57112929:A:C | observed | AKAP1 | 17 | AKAP1:17:57112860:T:C | AKAP1:17:57112929:A:C | 69 | 97 | 97 | 97 |
CNTNAP3:9:39090001:G:A|CNTNAP3:9:39090041:A:G | observed | CNTNAP3 | 9 | CNTNAP3:9:39090001:G:A | CNTNAP3:9:39090041:A:G | 40 | 83 | 41 | 4 |
PKHD1:6:51628851:T:A|PKHD1:6:51628862:T:C | observed | PKHD1 | 6 | PKHD1:6:51628851:T:A | PKHD1:6:51628862:T:C | 11 | 11 | 126 | 1 |
KIF13A:6:17860389:A:T|KIF13A:6:17860430:C:A | observed | KIF13A | 6 | KIF13A:6:17860389:A:T | KIF13A:6:17860430:C:A | 41 | 56 | 37 | 1 |
POMGNT1:1:46209110:C:T|POMGNT1:1:46209204:C:T | observed | POMGNT1 | 1 | POMGNT1:1:46209110:C:T | POMGNT1:1:46209204:C:T | 94 | 17 | 26 | 1 |
PPP1R26:9:135484544:C:T|PPP1R26:9:135484642:C:T | observed | PPP1R26 | 9 | PPP1R26:9:135484544:C:T | PPP1R26:9:135484642:C:T | 98 | 11 | 62 | 2 |
PALS2:7:24682194:A:G|PALS2:7:24682253:G:A | observed | PALS2 | 7 | PALS2:7:24682194:A:G | PALS2:7:24682253:G:A | 59 | 17 | 225 | 17 |
SEPTIN7:7:35858419:G:A|SEPTIN7:7:35858509:C:T | observed | SEPTIN7 | 7 | SEPTIN7:7:35858419:G:A | SEPTIN7:7:35858509:C:T | 90 | 14 | 28 | 2 |
DAG1:3:49471395:T:G|DAG1:3:49471470:C:T | observed | DAG1 | 3 | DAG1:3:49471395:T:G | DAG1:3:49471470:C:T | 75 | 74 | 15 | 1 |
BMP7:20:57192504:C:G|BMP7:20:57192505:G:A | observed | BMP7 | 20 | BMP7:20:57192504:C:G | BMP7:20:57192505:G:A | 1 | 14 | 14 | 1 |
SLC13A5:17:6702631:T:C|SLC13A5:17:6702657:A:G | observed | SLC13A5 | 17 | SLC13A5:17:6702631:T:C | SLC13A5:17:6702657:A:G | 26 | 38 | 3 | 1 |
RPL24:3:101686021:T:C|RPL24:3:101686048:G:A | observed | RPL24 | 3 | RPL24:3:101686021:T:C | RPL24:3:101686048:G:A | 27 | 3 | 220 | 3 |
PPARD:6:35369503:G:T|PPARD:6:35369579:T:C | observed | PPARD | 6 | PPARD:6:35369503:G:T | PPARD:6:35369579:T:C | 76 | 27 | 55 | 1 |
INSYN1:15:73745632:C:G|INSYN1:15:73745679:A:G | observed | INSYN1 | 15 | INSYN1:15:73745632:C:G | INSYN1:15:73745679:A:G | 47 | 156 | 8 | 2 |
MMP11:22:23777951:A:G|MMP11:22:23777965:C:T | observed | MMP11 | 22 | MMP11:22:23777951:A:G | MMP11:22:23777965:C:T | 14 | 182 | 5 | 1 |
NDUFS8:11:68036297:G:C|NDUFS8:11:68036342:C:T | observed | NDUFS8 | 11 | NDUFS8:11:68036297:G:C | NDUFS8:11:68036342:C:T | 45 | 8 | 3 | 3 |
RPN1:3:128623335:G:A|RPN1:3:128623344:C:G | observed | RPN1 | 3 | RPN1:3:128623335:G:A | RPN1:3:128623344:C:G | 9 | 44 | 120 | 1 |
BRWD1:21:39287205:G:A|BRWD1:21:39287283:C:T | observed | BRWD1 | 21 | BRWD1:21:39287205:G:A | BRWD1:21:39287283:C:T | 78 | 92 | 24 | 4 |
LPP:3:188512329:G:A|LPP:3:188512422:C:T | observed | LPP | 3 | LPP:3:188512329:G:A | LPP:3:188512422:C:T | 93 | 85 | 14 | 10 |
VWF:12:5964078:A:G|VWF:12:5964082:C:T | observed | VWF | 12 | VWF:12:5964078:A:G | VWF:12:5964082:C:T | 4 | 25 | 17 | 1 |
KCNMB2:3:178757154:A:G|KCNMB2:3:178757220:G:C | observed | KCNMB2 | 3 | KCNMB2:3:178757154:A:G | KCNMB2:3:178757220:G:C | 66 | 16 | 52 | 2 |
RTN4RL1:17:1966614:G:C|RTN4RL1:17:1966705:G:A | observed | RTN4RL1 | 17 | RTN4RL1:17:1966614:G:C | RTN4RL1:17:1966705:G:A | 91 | 12 | 46 | 2 |
PARVA:11:12459450:A:T|PARVA:11:12459471:C:T | observed | PARVA | 11 | PARVA:11:12459450:A:T | PARVA:11:12459471:C:T | 21 | 164 | 10 | 2 |
EMC3:3:9991551:C:G|EMC3:3:9991575:G:T | observed | EMC3 | 3 | EMC3:3:9991551:C:G | EMC3:3:9991575:G:T | 24 | 33 | 41 | 1 |
ITGA9:3:37532161:T:C|ITGA9:3:37532188:G:A | observed | ITGA9 | 3 | ITGA9:3:37532161:T:C | ITGA9:3:37532188:G:A | 27 | 59 | 12 | 1 |
ELFN2:22:37388477:A:C|ELFN2:22:37388483:G:A | observed | ELFN2 | 22 | ELFN2:22:37388477:A:C | ELFN2:22:37388483:G:A | 6 | 225 | 31 | 8 |
ST3GAL1:8:133543989:G:C|ST3GAL1:8:133544017:C:T | observed | ST3GAL1 | 8 | ST3GAL1:8:133543989:G:C | ST3GAL1:8:133544017:C:T | 28 | 7 | 14 | 1 |
PLAA:9:26930306:G:A|PLAA:9:26930314:T:C | observed | PLAA | 9 | PLAA:9:26930306:G:A | PLAA:9:26930314:T:C | 8 | 56 | 3 | 1 |
NAA30:14:57403559:A:G|NAA30:14:57403650:C:T | observed | NAA30 | 14 | NAA30:14:57403559:A:G | NAA30:14:57403650:C:T | 91 | 202 | 10 | 3 |
SUN2:22:38784178:G:A|SUN2:22:38784200:G:A | observed | SUN2 | 22 | SUN2:22:38784178:G:A | SUN2:22:38784200:G:A | 22 | 217 | 7 | 1 |
TMEM229B:14:67488281:C:A|TMEM229B:14:67488310:G:A | observed | TMEM229B | 14 | TMEM229B:14:67488281:C:A | TMEM229B:14:67488310:G:A | 29 | 68 | 3 | 1 |
MYO9A:15:71827228:C:T|MYO9A:15:71827295:A:G | observed | MYO9A | 15 | MYO9A:15:71827228:C:T | MYO9A:15:71827295:A:G | 67 | 129 | 60 | 1 |
COL5A1:9:134709977:G:A|COL5A1:9:134710002:C:T | observed | COL5A1 | 9 | COL5A1:9:134709977:G:A | COL5A1:9:134710002:C:T | 25 | 9 | 55 | 8 |
KCNN3:1:154785582:T:C|KCNN3:1:154785584:T:C | observed | KCNN3 | 1 | KCNN3:1:154785582:T:C | KCNN3:1:154785584:T:C | 2 | 48 | 36 | 1 |
GALNT17:7:71288412:G:A|GALNT17:7:71288426:C:T | observed | GALNT17 | 7 | GALNT17:7:71288412:G:A | GALNT17:7:71288426:C:T | 14 | 3 | 245 | 1 |
KHSRP:19:6416017:G:A|KHSRP:19:6416094:C:T | observed | KHSRP | 19 | KHSRP:19:6416017:G:A | KHSRP:19:6416094:C:T | 77 | 84 | 31 | 3 |
BRWD1:21:39252193:G:C|BRWD1:21:39252244:C:T | observed | BRWD1 | 21 | BRWD1:21:39252193:G:C | BRWD1:21:39252244:C:T | 51 | 6 | 46 | 1 |
REST:4:56931414:G:A|REST:4:56931415:G:C | observed | REST | 4 | REST:4:56931414:G:A | REST:4:56931415:G:C | 1 | 44 | 11 | 1 |
End of preview. Expand in Data Studio
CONSTRAINED TCGA-silent control (Panel F)
84,848 cis-double SNV pairs across 261 randomly sampled genes: LOEUF<0.7, ZERO TCGA pairs in any tier. Null reference.
Built with the standard paper §2 ¶1-5 methodology:
- ≤100 nt intra-gene window
- ≥3 1KG carriers per constituent
- TopLD r² ≥ 0.2 dropped
- Greedy 1:1 matched arms keyed on gene + log-rarity bin + distance ±2 nt
- seed=42
Companion panels:
splicing_epistasis_okgp_cons_driver_tcgarec— Panel Dsplicing_epistasis_okgp_cons_nondriver_tcgarec— Panel Esplicing_epistasis_okgp_cons_silent_control— Panel F
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